Sponsored by the Agency for Healthcare Research and Quality (AHRQ), VA/HSR&D, and Kaiser Permanente, this supplemental issue of the Journal of general internal medicine on implementation science (IS) and quality improvement (QI) marks the formal addition of IS/QI as an area of emphasis for JGIM. This is important because research without action seems incomplete. Moreover, the current pandemic has demanded accelerated implementation within every healthcare system across the globe and has revealed strengths as well as challenges. The articles in this supplement are examples of how HSR&D and QUERI investigators have worked to effectively implement evidence-based research findings within clinical practice. The supplement features innovative research that applied evidence across diverse delivery systems and settings.