Nice guideline [NG191]: Many of the recommendations made early in the pandemic were based on the consensus of the guideline expert panels, so supporting information is limited. We have reviewed all content, using topic expert input and more recent evidence, and updated the recommendations where needed. We aim to update these recommendations frequently in line with new evidence and will produce new recommendations where gaps are identified. We search and sift the evidence weekly to produce living recommendations that reflect the latest best available evidence. We have developed this guideline using our methods and processes for guidelines developed during health and social care emergencies. For more details of the methods and processes used for this guideline, including details of the expert advisory panel members, see the methods and processes section.